Scientific sessions, CRG Group Leader Seminars
Genome Architecture Group, Bioinformatics and Genomics Programme, CRG
Guillaume Filion started his doctoral research on epigenetics at the Curie Institute in 2004, under the supervision of Dr. PA Defossez. In 2008, he moved to the Netherlands, as a post-doc in the laboratory of Dr. B van Steensel. In 2012, he obtained a junior group leader position at the CRG.
We are working on the TRiP (Thousands of Reporters in Parallel) technology to study the influence of the chromatin context on gene expression. The technology is based on Sleeping Beauty transposition, random barcoding and high throughput sequencing. Our preliminary results in Drosophila cells suggest that transgenes inserted in the neighborhood of silent genes are transcribed. This invalidates the model that heterochromatin domains intrinsically repress transcription and suggest that more complex models are required.