Scientific sessions, CRG Group Leader Seminars
Comparative Bioinformatics Group, Bioinformatics and Genomics, CRG
Cedric Notredame did his PhD with Des Higgins at EMBL-Heidelberg and EMBL-EBI. After a Post doc at the NIMR-MRC in the lab of Wily Taylor, he moved to Marseilles as a CRNS staf scientist, in the lab of Jean-Michel Claverie. Cedric was then a PI in Lausanne (SIB-UNIL) before joining the CRG in 2007 where he is a senior PI in Roderic Guigo's Bioinformatics and Genomics program. Cedric's lab focuses on the development of methods for sequence and structural comparison, with a strong interest in Long Non Coding RNAs and their evolution.
During this seminar I will present some of the tools we have developed in the lab for the structure-based classification of protein sequences (iRMSD, T-RMSD) and show how these tools have been used to reclassify the Cystein Rich Domain receptor family and identify processes of convergent structural evolution. I will then develop more recent work in which we show how TCS, a novel consistency based reliability index, can be used to identify both evolutionary informative sites and structural correct positions. These observation suggest that structural characters may lend themselves to regular evolutionary analysis. All tools are freely available as web-servers, binaries or source codes from www.tcoffee.org.