04/02/2015 - 12:00 - Auditori PRBB

Asymmetric partitioning of a deacetylation enzyme promotes cell differentiation

Scientific sessions, CRG Group Leader Seminars

Manuel Mendoza

Coordination of Cytokinesis with Chromosome Segregation Group, Cell and Developmental Biology Programme, CRG

Short biography

Manuel Mendoza did his PhD studies at the IMP (Vienna). As a postdoctoral fellow he worked in cell polarity and division in fission and budding yeasts, first at the EMBL (Heidelberg) and later at the ETH (Zurich). His group at the CRG studies various aspects of cell division in eukaryotic cells, such as chromosome segregation, mitotic chromosome structure and cytokinesis.


A cell can generate progeny that is different from itself by ensuring that differentiation factors are inherited by only one of the daughter cells during cytokinesis. I will present recent data from our lab indicating that unequal partitioning of a lysine deacetylase is important for establishing mother - daughter asymmetries in budding yeast cells. The possible impact of these findings in the generation of distinct cell fates in higher eukaryotes will be discussed.