11/03/2015 - 12:00 - Auditori PRBB

Are all fit cells alike? Are all unfit cells unfit in their own way?

Scientific sessions, CRG Group Leader Seminars

Lucas Carey

Single Cell Behavior Lab, Evolutionary Biology and Complex Systems Programme, Dept. CEXS, UPF

Brief bio

Lucas Carey worked on transcription in yeast at Stony Brook with Bruce Futcher. He then moved to the Weizmann Institute to work on noise in transcription in yeast with Eran Segal. In October 2013 he started his own group at the CEXS-UPF where he's still working on transcription, and has added other forms of phenotypic noise to the list.


In an isogenic population of cells in a constant environment, ~10% of cells have lower fitness for purely stochastic reasons. Why? Does this help the population? What are the molecular mechanisms that determine the fraction of slow and fast cells? How does the cellular state of slow vs fast cells differ?  This talk will offer partial answers to some of these questions.