29/06/2012 - 12:00 - Sala Marie Curie

Ribosome biogenesis: Cell cycle checkpoints and cancer progression

Scientific sessions, PRBB CRG Conferences

George Thomas

Department of Oncology and Hematology, Metabolic Disease Institute, College of Medicine. Cincinnati, USA and ICO-IDIBELL. Barcelona, Spain

Gearge Thomas is recognized for the purification and cloning of the cell-signalling molecules S6K1 and S6K2. Dr. Thomas's laboratory is focused on elucidating the role of these kinases in cell growth, and is responsible for the identification of the upstream regulatory components that control their activity, including the TSC1/TSC2 tumor suppressor complex. Recently, the Thomas group has focused on the role that this pathway plays in the regulation of appetite and energy balance, the pathogenesis of metabolic disorders such as insulin resistance and diabetes, and the pathogenesis of cancer-related syndromes such as type 1 neurofibromatosis.

The Thomas laboratory has recently shown that S6K1 plays a critical role in a negative feedback loop to monitor insulin signaling, and is following up on this observation to study how the pathologies underlying cancer, obesity and diabetes are intimately linked through mTOR/S6K signaling.