17/06/2015 - 12:00 - Auditori PRBB

Chromatin dynamics in gene regulation

Scientific sessions, CRG Group Leader Seminars

Miguel Beato

Chromatin and Gene Expression Group, Gene Regulation, Stem Cells and Cancer Programme, CRG

Miguel Beato is a molecular biologist and senior scientist at the “Gene Regulation, Stem Cells and Cancer” programme of the CRG. He studied Medicine in Barcelona and did his MD and PhD in Germany. After 3 years as postdoc in Columbia University New York, he returned to Marburg in Germany, where he founded the Institute for Molecular Biology and Tumour Research (IMT) that he directed 1990-95. In 1998 he participated in the establishment of the Department of Experimental and Health Sciences (CEXS) of the Universitat Pompeu Fabra, and in 2000 he started the Center for Genomic Regulation (CRG), of which he was Director until June 2011. He is now Senior Group Leader and since June 2014 he coordinates the ERC Synergy Grant on 4D human genome structure.

His research is centered on the molecular mechanisms underlying the control of eukaryotic gene expression by steroid hormones. In the last years he has focused on the role of chromatin dynamics and how it is affected by crosstalk of the hormone receptors with kinase signaling cascades. His talk will summarize recent results on the dynamics of chromatin changes taking place in the genome of breast cancer cells exposed to progestins and on how the energetic demands of these processes are covered by the nuclear generation of ATP.