Scientific sessions, CRG Group Leader Seminars
Reprogramming and Regeneration Group, Gene Regulation, Stem Cells and Cancer Programme, CRG
Maria Pia Cosma was a Marie Curie Postdoc at IMP, Vienna, from 1997-2000. In 2003, she became a Young Group Leader at TIGEM, Naples, and an EMBO Young Investigator (YIP). From 2004 to 2010, she was a Lecturer at the European School of Molecular Medicine, Naples. In April 2010, she moved to the CRG, Barcelona, Spain, as a Senior Scientist and ICREA Research Professor. She is an awardee of: Marie Curie Excellence Award (2005); ERC Starting Grant (2009); HFSP Grant (2010). She received the Order of Merit of the Italian Republic in 2007, and became an EMBO Member in 2010.
The main interests of my group are to dissect the mechanisms and factors controlling somatic cell reprogramming and tissue regeneration in mammalians. Oscillations of Wnt/ß-catenin signaling, a key pathway regulating differentiation, are essential during development. We are therefore interested in studying the dynamics of the pathway in the control of pluripotency, somatic cell reprogramming and tissue regeneration. We use experimental and modeling approaches to associate the pathway dynamics to biological functions. Moreover, by using super resolution microscopy we have recently identified a novel model of chromatin fiber assembly and the relation among the decoded structure and naïve pluripotency. We are now investigating the temporal remodeling of the chromatin fiber in cells undergoing differentiation and reprogramming upon perturbation of the Wnt pathway.