07/09/2015 - 12:00 - Sala Marie Curie

Using fluorescent in situ sequencing (FISSEQ) to link genetic, phenotypic, and microenvironmental traits in cancer cell evolution

Scientific sessions, PRBB CRG Conferences

Je Lee

Tufts School of Medicine, Cold Spring Harbor Laboratory. New York, USA

Je Lee, from Cold Spring Harbor Laboratory in New York, US, studies how cells interact with their microenvironment to regulate gene expression during development. He has recently developed a method to sequence RNA molecules directly within single cells and tissues using sub-cellular resolution imaging. He focuses on the role of non-coding RNA in chromatin remodeling and tumor progression using mouse and organoid models of human cancer, using in situ sequencing, cell lineage tracing, and single-cell profiling.

He has been invited by Ben Lehner (CRG).