13/04/2016 - 12:00 - Auditori PRBB

Lipid sorting at the intersection between autophagy and endocytosis

Scientific sessions, CRG Group Leader Seminars

Christopher Burd

Department of Cell Biology, Yale University School of Medicine. New Haven, USA (Severo Ochoa visiting scientist)


Chris Burd obtained his PhD in Biochemistry and Molecular Biology from Northwestern University (Evanston, IL USA) in 1994. His thesis studies with Gideon Dreyfuss demonstrated specific RNA sequence recognition by hnRNP proteins, opening the door to understanding the roles of these proteins in mRNA maturation and trafficking. His postdoctoral studies with Scott Emr at the Howard Hughes Medical Institute at the University of California, San Diego, led to the first identification of phosphatidylinositol 3-kinase signaling effectors at the endosome. As an independent investigator, first at the University of Pennsylvania School of Medicine, and since 2011 at the Yale School of Medicine, he leads a research group that implements a wide range of experimental tools and organisms to investigate regulation of organelle biogenesis by phosphatidylinositol kinase signaling modules. Burd is currently Professor and Deputy Chairman of the Department of Cell Biology at the Yale School of Medicine in New Haven, CT (USA) and he is currently a Severo Ochoa visiting scientist at the CRG.

Talk Summary

Each organelle of the cell is composed of a unique repertoire of macromolecules that endows each organelle with its specific functions. Much is known regarding the mechanisms and principles that govern specific targeting of organelle resident proteins, but how is the lipid composition of each organelle established? And, how is organelle lipid composition buffered in response to dynamic changes in lipid metabolism and inter-organelle trafficking? I will present studies that elucidate key factors that mediate protein and lipid trafficking within the endo-lysosomal system of budding yeast (Saccharomyces cerevisiae), emphasizing new findings that link lipid sorting in the endosome to autophagy.