08/06/2016 - 12:00 - Auditori PRBB

Translational control in health and disease

Scientific sessions, CRG Group Leader Seminars

Fátima Gebauer

Regulation of Protein Synthesis in Eukaryotes Group, Gene Regulation, Stem Cells and Cancer Programme, CRG

Fátima Gebauer obtained her PhD in Sciences from the Autónoma University of Madrid, and performed postdocs in the labs of Joel Richter (UMass, USA) and Matthias Hentze (EMBL, Germany) studying the regulation of mRNA translation in vertebrate and invertebrate embryonic development. Her main interests focus on molecular mechanisms of translational control. She contributed to the field of cytoplasmic polyadenylation demonstrating its relevance for mammalian meiotic progression, and established in vitro systems that allow the molecular analysis of translation events. In 2002, she obtained a Group Leader position at the CRG, where her group is analyzing the role of RNA binding proteins in mRNA translation, development and cancer.

My talk will focus on the regulation of mRNA translation by RNA binding proteins, how they can either activate or repress translation, and why this is important for development. We have classically used Drosophila as a model system, but our recent experiments in Drosophila have led us to study cancer progression in humans. I will present the basis for this "evolution" and our progress in the understanding of melanoma, one of the most therapeutically challenging diseases.