Scientific sessions, CRG Group Leader Seminars
Coordination of Cytokinesis with Chromosome Segregation Group, Cell and Developmental Biology Programme, CRG
Manuel Mendoza obtained his PhD from the University of Vienna in 2002, working on the biochemistry of cytokinesis proteins under the supervision of Michael Glotzer. He then trained with Damien Brunner (EMBL, Heidelberg) and Yves Barral (ETH Zurich) studying cell polarity and cell division mechanisms in fission and budding yeasts. Manuel leads the Chromosome Segregation and Cytokinesis Group at CRG since 2008.
Living cells have a fascinating ability to generate complex and dynamic internal structures. Nowhere is this property more evident than during cell division: in only a few minutes, cells alter their shape, duplicate and partition their internal components, and divide into two apparently identical halves, which in many cases go on to acquire distinct identities. These dramatic changes need to be carefully coordinated with each other in space and time. To gain insight into these processes, we focus on two major cell cycle transitions. First, we study how chromosome segregation and cytokinesis are coordinated with each other. Second, we are interested in mechanisms that establish differences in nuclear organization after asymmetric cell division to regulate cell fate.