03/10/2016 - 12:00 - Sala Marie Curie

Molecular dynamics of cell fate decisions

Scientific sessions, PRBB CRG Conferences

Christian Schröter

Max Plank Institute of Molecular Physiology. Dortmund, Germany

Schröter, from the Max Plank Institute of Molecular Physiology in Dortmund, Germany, is interested to understand how the dynamic activities of molecular networks guide cell fate choice. This requires quantitative, time-resolved and simultaneous measurements of the activity of network components in single cells. These data can then inform and constrain mathematical models to describe the behavior of these networks, and to formulate generic rules of the connection between network dynamics and fate decisions. Understanding the regulation of cell differentiation at this level is an attractive intellectual challenge in itself; furthermore, it will be crucial for the targeted differentiation of stem cells for regenerative approaches in vitro, and for the development of novel treatments in cases where cell fate choice fails, such as congenital diseases and cancer.