07/12/2012 - 12:00 - Sala Marie Curie

Pathway-driven prediction of mutation impact in cancer

Scientific sessions, PRBB CRG Conferences

Josh Stuart

Systems Biology Group, UC Santa Cruz. Santa Cruz, USA

Josh Stuart, from the Systems Biology Group of the University of California, Santa Cruz, in the USA, uses data-driven approaches to identify and characterize genetic networks, investigate how they've evolved, and then use them to simulate and predict cellular behavior. His approach is to design computational models and algorithms that integrate high-throughput molecular biology datasets (genomic, epigenomic, and functional genomic) to predict cellular- and organism-level phenotypes. He particularly focuses on elucidating altered signaling pathways in cancer cells that initiate and drive tumorogenesis and is developing models to predict the impact of mutations in human tissue and a patient's response to treatment. He participates in the analysis of data from The Cancer Genome Atlas project. He has been invited by Nuria López-Bigas (UPF).