12/12/2016 - 12:00 - Sala Marie Curie

Genomics of aging

Scientific sessions, PRBB CRG Conferences

Vadim Gladyshev

Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School. Boston, USA

Vadim Gladyshev, from the Brigham and Women’s Hospital, Harvard Medical School in Boston, USA, is trying to uncover the molecular basis for natural changes in longevity by identifying adaptations in long-lived mammals and examining longevity-associated processes across all mammals. For the past couple of years, he has had an active research program on the mechanisms of aging. His group is now characterizing properties of cumulative damage and its impact on the aging process. He is also trying to understand the mechanisms of redox regulation of cellular processes. To understand mechanisms of redox control and its role in aging and cancer, it is necessary to know identities and functions of participants in the redox process. Thus, he is developing bioinformatics approaches and carrying out genome sequencing, proteomics and functional genomics studies, which are followed with in vitro and in vivo tests of the identified targets. He is particularly interested in the redox control that involves specific and stochastic oxidation of cysteine and methionine residues in proteins. He has been invited by Roderic Guigó (CRG).