23/11/2016 - 12:00 - Auditori PRBB

Why, if you are so good, do not you do it yourself? A journey in protein-RNA networks

Scientific sessions, CRG Group Leader Seminars

Gian Gaetano Tartaglia

Gene Function and Evolution Group, Bioinformatics and Genomics Programme, CRG

In my talk I will update on the newest developments of the lab. I will present some of the latest methods developed to predict protein-RNA interactions and present examples of intriguing cases that we recently studied. In the last year a number of articles reported that the non-coding Xist interact with specific RNA-binding protein networks. Yet, the physical association between Xist and most of the proteins is under debate. We used our computational approach, Global Score, to identify direct targets of the molecule. In addition, we started to develop models to predict the RNA-structure of long non-coding RNA and to rationalize their partner networks. Finally, I will introduce our work on the identification of non-canonical RNA-binding proteins.

Short biography:
Gian graduated at the University La Sapienza in the academic year 1999-2000 with a thesis on mathematical modeling of neurons (Physics department). Between 2001 and 2005, he carried out the doctoral studies at the University of Zurich in Switzerland (Biochemistry department) focusing on the folding and misfolding of proteins associated with neurodegenerative disorders. As an associate researcher, Gian worked at the University of Cambridge, UK (Chemistry and Genetics departments) under the supervision of Chris Dobson and Michele Vendruscolo. In the period 2005-2010, he participated in several computational and experimental studies on amyloidosis. Gian started his laboratory at the Centre for Genomic Regulation (Barcelona, Spain) in 2010 and became professor of Institució Catalana de Recerca i Estudis Avançats (ICREA) in 2014.