26/05/2017 - 12:00 - Sala Marie Curie

Regulation of self-renewal in cancer stem cells

Scientific sessions, PRBB CRG Conferences

Pier Giuseppe Pelicci

Department of Experimental Oncology, Campus IFOM-IEO. Milan, Italy

Pier Giuseppe Pelicci, from the IEO in Milan, Italy, aims to generate appropriate mouse model systems of human cancer for the characterization of cancer stem cell properties and their molecular determinants. He is also investigating the effects of metabolism and checkpoint activation in stem cells (SCs) on tissue homeostasis and ageing. He focuses on the characterization of the cancer stem cells-specific properties of self renewal and differentiation, and their underlying molecular mechanisms, using mouse models of human leukemias and mammary cancer. He also works on the characterization of the physiological significance of the p66Shc signaling pathway. He has been invited by Luciano Di Croce (CRG).