15/06/2012 - 12:00 - Sala Marie Curie

Histone modification and exchange during transcription

Scientific sessions, PRBB CRG Conferences

Jerry L. Workman

Stowers Institute for Medical Research. Kansas City, USA

Workman, from the Stowers Institute for Medical Research in Kansas City, USA, is interested in protein complexes that modify chromatin and regulate gene transcription. He focuses on studying the protein complexes that carry out histone modifications and those that recognize the resulting signals. Workman works with yeast, flies and mammalian cells. Recent research in yeast has resulted in the discovery of the Set2/Rpd3S pathway, by which RNA polymerase II signals through histone methylation for the retention of the original histones on a gene during transcription and the deacetylation of histones in the wake of the polymerase. In flies, he discovered the role of the Tip60 acetyltransferase complex in histone-variant modification and exchange during DNA repair. He has been invited by Francesc Posas (UPF).