12/12/2012 - 12:00 - Auditori PRBB

The family of DYRK protein kinases

Scientific sessions, CRG Group Leader Seminars

Susana de la Luna

Genes and Disease Programme, CRG

Susana de la Luna is a group leader at the CRG (first at Genes and Disease Program and now at Gene Regulation, Stem Cells and Cancer Program). She received her PhD in 1990 from the Autónoma University of Madrid, where she was trained in Molecular Virology. She performed a postdoc in the lab of Nicholas B. La Thangue (NIMR-MRC, London) on transcriptional regulation of the G1/S transition of the mammalian cell cycle. In 1999 she was appointed Staff Scientist at the Institut de Recerca Oncologica (Barcelona), and in 2002 she obtained a group leader position at the CRG as an ICREA Researcher. S. de la Luna is interested in a family of protein kinases known as DYRK kinases with special focus on one of its members, DYRK1A, and its relationship to human disease. 

Talk summary:

Members of the DYRK family are found in four of the five main taxa, and all DYRK proteins studied to date share common structural, biochemical and functional properties with the ancestral forms represented by yeast. Recent work on DYRK proteins indicates that they participate in several signaling pathways critical for developmental processes and cell homeostasis. During my talk, I will summarize current knowledge on the family with special emphasis on DYRK1A and I will present recent work of the group on a novel role of DYRK1A in transcriptional regulation.