06/07/2012 - 12:00 - Sala Ramón y Cajal

Insights into microRNA processing, mechanism and function from zebrafish

Scientific sessions, PRBB CRG Conferences

Antonio Giráldez

Biological & Biomedical Sciences Program, Yale University. New Haven, USA

Antonio Giráldez, from the Biological and Biomedical Sciences Program at the Yale University in New Haven, USA, will give a talk entitled "Insights into microRNA processing, mechanism and function from zebrafish" on Friday July 6 at 12:00 at the Ramón y Cajal room of the PRBB (C/ Dr. Aiguader, 88). He was invited by Fátima Gebauer (CRG).

Giráldez is interested in the role of microRNAs during vertebrate development using zebrafish as a model system. He combines genetics, embryology, genomics, biochemistry, and computational biology to address a central question in biology: how does a fertilized egg develop into a complex multicellular embryo. In particular he is interested in a long standing problem in developmental biology the maternal to zygotic transition. Giraldez is using microarray analysis in dicer mutant embryos to identify tissue specific microRNA targets in neurons and muscle cells. With computational projects he is analyzing the regulatory motifs in microRNAs and 3’UTR elements of their targets to identify the gene networks controlled by microRNAs. He is combining in vivo target identification with phenotypic characterization of dicer mutants in order to understand the function of tissue specific microRNAs during cell fate specification and tissue homeostasis.