20/02/2013 - 12:00 - Auditori PRBB

Toward specific functions of Parp-2 in the DNA damage response

Scientific sessions, CRG Group Leader Seminars

José Yélamos

Cancer Research Program, IMIM-Parc de Salut Mar


José Yélamos is a group leader at the Cancer Research Program of the IMIM. He obtained his PhD in 1993 from the University of Sevilla. After a postdoc in the lab of César Milstein (MRC-LMB, Cambridge), he established his laboratory at the University of Murcia in 1999 supported by FIS and Ramón y Cajal Programs. In 2007 he joined the Hospital del Mar as Immunologist.

Talk summary

His main research interest is to investigate the role of a family of proteins known as Poly(ADP-ribose) polymerases (Parp), especially Parp-2, in the immune system as component of the DNA damage response pathways in lymphocytes and their implications in genomic instability and cancer. In his talk he will address the specific roles of Parp-2 in the complex networks that have been developed by haematopoietic cells to response to DNA damage, through DNA repair, DNA damage-dependent apoptotic and cell-cycle checkpoint pathways, and their implications in genomic instability and cancer.