14/06/2013 - 12:00 - Sala Ramón y Cajal

Increased chromosome mobility facilitates homology search during double-strand break repair

Scientific sessions, PRBB CRG Conferences

Rodney Rothstein

Department of Genetics & Development, Columbia University Medical Center. New York, USA

Rodney Rothstein, from the Department of Genetics & Development at Columbia University Medical Cente in New York, USA, is using budding yeast to study the mechanisms underlying the recognition and repair of DNA damage and the role that genetic recombination plays during repair. He focuses onthe central recombination protein Rad52, theribonucleasereductase inhibitor Sml1, and the topoisomerase helicase complex Top3/Sgs1. His group also develops methods to enhance the utility of a complete gene disruption library in order to facilitate genome-wide analysis of not only budding yeast, but other species as well.He has been invited by Luis Serrano (CRG).