23/10/2013 - 12:00 - Auditori PRBB

Chromosomes do the (un)twist: mechanisms of DNA decatenation during cell division

Scientific sessions, CRG Group Leader Seminars

Manuel Mendoza

Coordination of Cytokinesis with Chromosome Segregation Group, Cell and Developmental Biology Programme, CRG

Biographical sketch:

Manuel Mendoza is a cell biologist interested in the regulation of chromosome segregation and cytokinesis. His PhD work was conducted at the IMP in Vienna, and his postdoctoral training at EMBL (Heidelberg) and ETH (Zurich). His laboratory uses budding yeast and Drosophila as model systems to understand the mechanisms of chromosome condensation and segregation, and how these processes are coordinated with cytokinesis to maintain genomic stability.


His talk will describe recent advances in our understanding of the origin and processing of intertwines between replicated chromosomes. Specifically, he will show that the level of intertwining between sister DNAs is a function of chromosome arm length and of chromosome topological constraints within the cell nucleus; and that intertwine resolution requires not only Topoisomerase II, but also microtubule dynamics during cell division. He will also describe how persistent intertwining triggers dedicated cell cycle checkpoints to prevent DNA damage by cytokinesis.

The next Group Leader Seminars will be:

Toni Gabaldón, CRG, November 6. Auditorium
Pura Muñoz, CEXS-UPF, November 13. Marie Curie