10/02/2014 - 12:00 - Sala Marie Curie

The 5-HT6 receptor associated complex: new signaling pathways involved in neuronal differentiation and cognition

Scientific sessions, PRBB CRG Conferences

Philippe Marin

Department of Neuroscience and Cell Biology, Institut de Génomique Fonctionnelle, INSERM. Montpellier, France

Philippe Marin, from the Department of Neuroscience and Cell Biology at the Institut de Génomique Fonctionnelle in Montpellier, France, uses functional proteomics approaches to identify signalling networks associated with various serotonin receptors and with the serotonin transportar. The aim is to characterizes their role in synaptic transmission and synaptic plasticity, cognition, mood and neuronal survival. Serotonin is a major neurotransmitter of the mammalian central nervous System and it is involved in numerous physiological functions including the regulation of mood, cognitive functions, feeding, sleep and pain transmission. Alterations of serotonergic systems have been involved in numerous psychiatric disorders such as mood disorders and psychoses. Accordingly, serotonin receptors and the serotonin transporter (SERT) are major targets of numerous psychoactive medications including the majority of currently available antidepressants and atypical antipsychotics. Marin has been invited by Rafael Maldonado (UPF).