27/01/2014 - 12:00 - Sala Charles Darwin

Looking at the molecular pathways regulating T cell acute leukemia development using humanized in vitro and in vivo models: surprising micro-environment!

Scientific sessions, PRBB CRG Conferences

Françoise Pflumio

Institut de Radiobiologie Cellulaire et Moléculaire. Fontenay-aux-Roses, France

Françoise Pflumio, from Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), in France, studies the mechanisms that maintain stem cell quiescence and those that allow them to enter the cell cycle and differentiate into different hematopoietic lineages. She is also working on the characterization of the leukemic stem cells and trying to understand their resistance to drugs. In order to determine the functions of transcription factors and signalling pathways regulating normal hematopoiesis and leukemia, her group combines genetic, molecular and cellular approaches with imaging to monitor the development of leukemia or the initiation of normal hematopoiesis in xenograft models. She has been invited by Anna Bigas (IMIM).