Scientific sessions, CRG Group Leader Seminars
Mechanisms of Cancer and Aging Group, Gene Regulation, Stem Cells & Cancer Programme, CRG
Bill Keyes obtained his PhD at the University of Alberta, Edmonton, Canada, in the lab of Esmond Sanders, studying the role of apoptosis in early heart development. From there, he moved to Cold Spring Harbor Laboratory, NY, USA to pursue postdoctoral research in the lab of Alea Mills, investigating the role of p63 in cancer and aging. In 2009, he joined the CRG to start his lab investigating common mechanisms of cancer and aging.
His current research is centered on the investigation of the mechanisms of how tumor development begins, and how aging is regulated at the level of the stem cell. This includes studying how mutations can overcome the tumor suppressive mechanism of cellular senescence, as well as investigating new mechanisms of regulation and biological functions for senescence. In addition, they are interested in understanding how stem cells are affected by aging, and how this might play roles in the aging process and tumor initiation. In his talk, hewill present two ongoing projects related to the processes of tumor initiation and metastasis.