IMIM: Order matters: sequence of genetic mutations determines how cancer behaves

IMIM: Order matters: sequence of genetic mutations determines how cancer behaves

News from IMIM

The Hospital del Mar is the only Spanish center that has participated in the study led by the University of Cambridge and published in the journal The New England Journal of Medicine.

Most of the genetic mutations that cause cancer result from environmental ‘damage’ (for example, through smoking or as a result of over-exposure to sunlight) or from spontaneous errors as cells divide. In a study published today, researchers at the Department of Haematology, the Cambridge Institute for Medical Research and the Wellcome Trust/Medical Research Council Stem Cell Institute show for the first time that the order in which such mutations occur can have an impact on disease severity and response to therapy.  

The researchers examined genetically distinct single stem cells taken from patients with myeloproliferative neoplasms (MPNs), a group of bone marrow disorders that are characterised by the over-production of mature blood cells together with an increased risk of both blood clots and leukaemia. These disorders are identified at a much earlier stage than most cancers because the increased number of blood cells is readily detectable in blood counts taken during routine clinical check-ups for completely different problems.

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IMIM news (Catalan)

"Effect of Mutation Order donde Myeloproliferative neoplasma" Christina A. Ortmann, MD, David G. Kent, Ph.D., Jyoti Nangal, MBChir., FRCPath., Yvonne Silber, M.Sc., David C. Wedge, Ph.D., Jacob Grinfeld, MB, Ch.B., FRCPath., E. Joanna Baxter, Ph.D., Charles E. Massie, Ph.D., Elli Papaemmanuil, Ph.D., Suraj Menon, Ph.D., Anna L. Godfrey, FRCPath., Ph.D., Danai Dimitropoulou, B.Sc., Paola Guglielmelli, MD, Ph.D., Beatriz Bellosillo, Ph.D., Carles Besses, MD, Ph.D., Konstanze Dohna, MD, Claire N. Harrison, DM, FRCPath., George S. Vassiliou, FRCPath., Ph.D., Alessandro VANNUCCHI, MD, Peter J. Campbell, MB, Ch.B ., Ph.D., and Anthony R. Green, FRCPath., F.Med.Sci. New England Journal of Medicine. DOI: 10.1056 / NEJMoa1412098