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29/5/2015

CEXS-UPF: Molecular dissection of intracellular iron regulation

CEXS-UPF: Molecular dissection of intracellular iron regulation


News from CEXS-UPF


Iron is an essential metal for organisms and is, in turn, toxic, which means that intracellular availability and its storage must be firmly subject to regulation. From prokaryotes (bacteria) to higher, more complex organisms, iron deficiency triggers complicated genetic responses to promote intracellular iron absorption and its use.

The Oxidative Stress and Cell Cycle research group at the Department of Experimental and Health Sciences (CEXS) at UPF, led by Elena Hidalgo and José Ayté , both co-authors of a paper that has been published in the journal PLOS Genetics in March studies the response of Schizosaccharomyces pombe yeast to deal with iron deprivation and the different types of regulation of cell gene expression programmes. Postdoctoral researchers Javier Encinar del Dedo and Natalia Gabrielli are first authors of this work.

In this study, the authors have performed a "complete molecular dissection of the components and the events that govern this cell signalling cascade in S. pombe yeast", explains Hidalgo. 

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Reference:
Encinar del Dedo J, Gabrielli N, Carmona M, Ayté J, Hidalgo E., (2015), "A cascade of iron-containing proteins governs the genetic iron starvation response to promote iron uptake and inhibit iron storage in fission yeast",  PLOS Genetics, 25;11(3):e1005106. doi: 10.1371/journal.pgen.1005106