News
19/6/2015

CEXS-UPF: How epithelial cells use forces and fluids to sculpt cavities during development

CEXS-UPF: How epithelial cells use forces and fluids to sculpt cavities during development


News from CEXS-UPF


Scientists from the Department of Experimental and Health Sciences at Universitat Pompeu Fabra identified new essential mechanisms exerted by epithelial cells to control the shape and growth of the developing zebrafish otic lumen. The paper published in "Nature communications" relies on high spatio-temporal resolution live imaging and performs for the first time a 4D quantitative analysis of lumen formation dynamics. The work was done by the the Developmental Biology Lab, led by Berta Alsina, and headed by Esteban Hoijman and with the contribution of Davide Rubbini.

Cell division during zebrafish inner ear hollowing from Esteban Hoijman on Vimeo.

Reference:
Hoijman Esteban, Rubbini Davide, Colombelli Julien, Alsina Berta. Mitotic cell rounding and epithelial thinning regulate lumen growth and shape. Nature Communications. 16th June 2015. DOI 10.1038/ncomms8355

More information:
CEXS-UPF website