News
23/10/2015

IMIM: Researchers identify a new therapeutic target for the most prevalent cutaneous lymphoma

IMIM: Researchers identify a new therapeutic target for the most prevalent cutaneous lymphoma


News from IMIM


Hospital del Mar researchers have found one of the key mechanisms of the development and progression of mycosis fungoides, a type of cancer originating in lymphoid cells which initially develops in the skin.

The study, published in the Journal of Investigative Dermatology, was co-led by Fernando Gallardo, a dermatologist at the Hospital del Mar and and researcher at the translational research group in hematological malignancies at the Hospital del Mar Medical Research Institute (IMIM), Luis Espinosa and Anna Bigas from the Laboratory of Cancer Stem Cells of IMIM, Juan Sandoval researcher at the Research Institute de la Fe (IISlaFe) and Angel Diaz, a researcher at the Institute of Biomedical Research of Bellvitge (IDIBELL).

The study was conducted with a number of skin samples from patients with mycosis fungoides in tumor stage and has identified the miR-200C molecule as a potential therapeutic target for designing future treatment of this disease.

More information:
IMIM news (in Spanish)

Reference:
Gallardo F, Sandoval J *, Díaz-Lagares A, Garcia R, De Ajena T, González J, Alegre V, Servitje O Crujeiras AB, Stefansson OA, Espinet B, Hernández-Muñoz I, Bellosillo B, Esteller M, Pujol RM, Bigas A *, Espinosa L *. Notch1 Pathway Activation Results from the epigenetica Abrogation of Notch-Related microRNAs in Mycosis Fungoides. J Invest Dermatol 2015.