News from the CEXS-UPF
Chronic HIV infection results in exhaustion of the immune system, a phenomenon characterized by dysfunctional T cells. The exhausted T cells display inhibitory proteins on their surface that could be the key for restoring the immune function in cases of immunosuppression. Andreas Meyerhans, leader of the Infection Biology Group of the Department of Experimental and Health Sciences (DCEXS) of Pompeu Fabra University (UPF), leads a research that suggests that interfering with the negative signals transmitted by such proteins could mprove the medical treatment against the human immunodeficiency virus. The results appear in an article signed by Cristina Peligero and published December 3rd in PLOS Pathogens.
Cristina Peligero, Jordi Argilaguet, Roberto Güerri-Fernandez, Berta Torres, Carmen Ligero, Pilar Colomer, Montserrat Plana, Hernando Knobel, Felipe García and Andreas Meyerhans. PD-L1 Blockade Differentially Impacts Regulatory T Cells from HIV-Infected Individuals Depending on Plasma Viremia . DOI:10.1371/journal.ppat.1005270 Plos Pathogens, December 2015.