IMIM: New genes formed continuously allow acquisition of novel functions during evolution

IMIM: New genes formed continuously allow acquisition of novel functions during evolution

News from IMIM

Research just published in the journal Plos Genetics has found that gaining new genes during evolution is a much more frequent event than previously thought. It has been seen that there are hundreds of genes that might be unique to humans, and something similar occurs in chimpanzees. Some of these genes will be useful for the organism in question and the rest will disappear in time. The work was led by Mar Albà, an ICREA researcher at the Mar Institute of Medical Research (IMIM) and Jorge Ruiz-Orera, from the same group, together with researchers from Pompeu Fabra University (UPF) and the Centre for Genomic Regulation (CRG).

For some time it was thought that all new genes originated from other genes, for example, from duplications of already existing genes. But recently it has been seen that some, the so-called de novo genes, originate in genomic regions that previously contained none. According to Mar Albà “This work shows that the formation of DNA motifs, through the accumulation of random mutations, would have been a determining factor in the emergence of new genes.” DNA motifs are elements that activate gene expression.

In the attached image the wooden pieces represent genes. We can see that the pieces are different colours, each representing the genes of a different species. We can also see that some forms resemble each other, for example, the triangle is found in all three species; it represents a gene created long ago that has been conserved. But occasionally entirely new forms appear that we can see in only one species, like the strangely-shaped piece in the middle row. These are de novo genes, formed through random mutations. The image was created by Will Blevins and José Luis Villanueva, researchers from the Evolutionary Genomics Group at the GRIB (IMIM-UPF).

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Reference article: 
Jorge Ruiz-Orera, Jessica Hernandez-Rodriguez, Cristina Chiva, Eduard Sabidó, Ivanela Kondova, Ronald Bontrop, Tomàs Marqués-Bonet, M.Mar Albà. Origins of de novo genes in human and chimpanzee. PLoS Genetics, Dec 31 2015