News from CREAL
A study published in Nature Genetics with the participation of CREAL, an ISGlobal allied centre, has identified three genetic variants associated with Subjective Well-Being (SWB), two with depressive symptoms (DS), and eleven with emotional instability or neuroticism, including two inversion polymorphisms. These inversions have been found thanks to a bioinformatics tool developed by Alejandro Cáceres and Juan Ramon González, from the Bioinformatics research group at CREAL. These researchers are also linked with the Pompeu Fabra University.
More than 190 researchers participated in this study that consisted in a two-phase analysis of SWB, depressive symptoms, and neuroticism. The main analysis consisted in a genome wide association study with SWB using 59 cohorts, with nearly 300,000 subjects. This analysis identified three loci (fixed positions in the genome) associated with SWB. The researchers validated these results with data published for depressive symptoms (180,000 subjects) and neuroticism (170,000 subjects).
“These analyses have allowed us to identify genetic variants associated with depressive symptoms and/or neurosis that are also correlated with SWB, and vice versa. The analysis performed by our group has allowed us to identify two inversion polymorphisms (genome regions where the sequence is inverted) that show a stronger association than the genetic variants normally analysed in these studies. These findings have been replicated in an independent sample of almost 369,000 subjects, making it the most important study to date for these pathologies” explains Juan Ramón González, co-author in the study.
Okbay A, et al. Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism. Nature Genetics. 2016. April 18