News from CEXS-UPF
The Computational Genomics research group at Pompeu Fabra University has discovered new alterations linked to cancer and has revealed the importance of the transcriptome in the development of tumours. For the first time, scientists have studied the variability of the cell transcriptome in several tumours at the same time, that is, not focusing on the DNA but on the products extracted from it. The results of the study have been published in the journal Genome Research.
The genetic information of cells is encoded in the DNA. This information is read by the cellular machinery, which will generate the so-called RNA and then translate it into proteins. Sometimes, the same gene can give rise to different RNA molecules, which may produce proteins with potentially very different functions. This is due to a process known as "alternative splicing", which influences the synthesis of most of the RNAs and proteins of eukaryotic cells and its regulation depends on the RNA-binding proteins (RBPs). The research team led by Eduardo Eyras, head of the Computational Genomics laboratory, has unveiled some alterations in RBPs that bring about changes in alternative splicing linked to the development of cancer.
Endre Sebestyén, Babita Singh, Belén Miñana, et al. Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks. Genome Research published online April 13, 2016. DOI:10.1101/gr.199935.115