News from CEXS-UPF
Scientists from the Neuropharmacology Laboratory at Pompeu Fabra University in collaboration with scientists from the University of Bordeaux (France) and the University of Mainz (Germany), have discovered the mechanism that underlies the harmful effect that produces stress in memory consolidation. The results are published in the latest edition of the journal Proceedings of the National Academy of Sciences.
This research, part of the doctoral thesis by Maria Gomis-González and led by Andrés Ozaita, examines the role of the endocannabinoid system in the consolidation of non-emotional memories in the face of stressful situations, finding the main role of the CB1 cannabinoid receptor in adrenergic/noradrenergic-type neurons. The activation of this receptor and the modulation it exerts on the release of norepinephrine, lead to the fact that in stressful situations failures can occur in the consolidation of non-emotional memories: in mice, following the pharmacological or even genetic blockade of CB1 cannabinoid receptors, genetic deficits of non-emotional memory typical of a stressful situation are not observed.
The results also show that, in addition to the participation of the central nervous system, peripheral agents such as the adrenal glands are involved in the memory failures described, revealing CB1 receptors as a key element in the process.
Arnau Busquets-Garcia, Maria Gomis-González, Raj Kamal Srivastava, Laura Cutando, Antonio Ortega-Alvaro, Sabine Ruehle, Floortje Remmers, Laura Bindila, Luigi Bellocchio, Giovanni Marsicano, Beat Lutz, Rafael Maldonado, Andrés Ozaita. Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. Proceedings of the National Academy of Sciences, August 2016.