IMIM: Key immunological mechanism for regulating intestinal flora discovered

IMIM: Key immunological mechanism for regulating intestinal flora discovered

News from IMIM

Researchers at the IMIM have shown for the first time that immunoglobulin M, secreted by the human intestine, plays a key role in maintaining the diversity of intestinal flora by including and maintaining microorganisms that are beneficial to our health. These results have been published in the journal Immunity.

"We have discovered that, in addition to immunoglobulin A (IgA), immunoglobulin M (IgM), secreted by the human intestine, interacts with the intestinal microbiota and actively participates in maintaining its diversity. In addition, we have demonstrated that this immunoglobulin is part of an immunological memory system through which our organism is able to recognise and adapt to its microbial environment", explain Giuliana Magri and Laura Comerma, researchers from the B Cell Biology research group at the IMIM and first authors of the article.

"Another conclusion of this work is that as well as acting as an agent of exclusion and removal of microorganisms, the IgM actively participates in the inclusion and maintenance of microorganisms that are beneficial for our health", says Giuliana Magri. "It provides key information for subsequent studies on the factors involved in the development and evolution of all pathologies associated with microbiotic alterations" she adds.

More information:
IMIM website

Reference article:
G.Magri, L.Comerma, M.Pybus, J.Sintes, D.Lligé, D.Segura Garzón, S.Bascones, A.Yeste, E.K.Grasset, C.Gutze , M.Uzzan, M.Ramanujam, M.C. van Zelm, R. Albero-González, I.Vazquez, M.Iglesias, S.Serrano, L.Márquez, E.Mercade, S.Mehandru, A. Cerutti. “Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals”. Immunity (2017).