News from IMIM
Researchers from the IMIM and IDIAP Jordi Gol have just published an article showing that autoimmune diseases significantly increase cardiovascular risk as well as overall mortality. This is particularly pronounced in people suffering rheumatoid arthritis or systemic lupus erythematosus. In addition, it has been seen that inflammatory bowel diseases, such as Crohn's or ulcerative colitis, increase the risk of stroke and death through any cause. The article has been published in the journal Heart.
The 6-year study followed a cohort of nearly 1 million people aged between 35 and 85, with no history of cardiovascular disease. The large sample size allowed the estimation of cardiovascular event incidence and mortality in people diagnosed with autoimmune diseases. Some of these diseases are relatively frequent, so their impact is quite significant.
The study results showed that systemic disorders of connective tissue, like lupus, and rheumatoid arthritis, are associated with a greater cardiovascular and overall mortality risk, followed by inflammatory bowel diseases, such as Crohn's and ulcerative colitis, which involve an increased risk of stroke and mortality. "It is believed that the increased risk of cardiovascular problems and mortality in rheumatoid arthritis and lupus is due to the interaction of inflammation, metabolic factors, therapy, and disease-related factors", explains María Grau, principal investigator on the article.
Baena-Díez JM, Garcia-Gil M, Comas-Cufí M, Ramos R, Prieto-Alhambra D, Salvador-González B, Elosua R, Dégano IR, Peñafiel J, Grau M. The Association Between Chronic Immune-Mediated Inflammatory Diseases and Cardiovascular Risk. Heart 2017.