News from CRG
The genome architecture has important informational value for controlling gene expression during cell reprogramming, and is thus required for the specialized functions of a cell. These findings of the “4D Genome Project” financed by the European Research Council add a new layer of complexity that needs to be studied to properly interpret genomics and gene expression in the future.
“Our paper shows that transcription factors may play a completely new role in cell reprogramming: they do not only switch genes on and off, but also promote the architectural changes necessary to modify gene expression,” states Thomas Graf, senior CRG group leader and lead investigator of this study. Previously he and his team had discovered a cellular reprogramming method, which was now used as a precision tool to study the dynamics of genome organization by comparing the changes in genome architecture and transcription at different times during reprogramming. - RF/PRBB
Ralph Stadhouders, et.al. Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming. Nature Genetics (2018).