News
2/2/2018

IBE + DCEXS-UPF: PopHuman - A browser to search human genetic diversity

IBE + DCEXS-UPF: PopHuman - A browser to search human genetic diversity


News from IBE and the UPF


An exhaustive inventory of genetic diversity measures along the human genome has been published in the internet portal PopHuman (pophuman.uab.cat). The data comes from the “1,000 genomes” project with a total of 2,504 complete genomic sequences from 26 populations around the world. It is the most extensive global human genetic variation data set to date, with more than 84 million genetic differences catalogued.

Jaume Bertranpetit and Hafid Laayouni from IBE and the UPF and researchers from the Bioinformatics of Genomic Diversity group at the Autonomous University of Barcelona (UAB) are convinced that PopHuman will become the starting point for any exhaustive analysis of the different selective episodes which have taken place in the human lineage and have left their mark on the genome. For example the establishment of agriculture in European and Asian populations some 10,000 years ago.

Human genetic variation is the set of genetic differences which distinguish our genomes, either among individuals within a population or between populations. There are no two genetically identical humans. On average, each of us is more than 99% genetically identical to any other person, while the less than 1% of genetic variants distinguishing our genomes are present in different frequencies in different human populations. The geographically and ancestrally more distant populations tend to differ more, although it is the differences between individuals within populations, especially in the African ones, the most important quantitatively in the set of the human genetic variation. - RF/PRBB

More information:
IBE news
DCEXS-UPF news

Reference article:
Sònia Casillas, et.al. PopHuman: the human population genomics browser, 2018. Nucleic Acids Research, 46(D1):D1003-D1010. https://doi.org/10.1093/nar/gkx943. Impact Factor: 10.162.