News from DCEXS-UPF
A fragment of the peptide crotalidicin, isolated from the venom of a South American rattlesnake, has shown its ability to kill bacteria without affecting healthy cells. This discovery, according to the researcher Sónia Troeira Henriques, of the Institute for Molecular Bioscience at the University of Queensland, Australia, is significant because of the increase in the strains of drug-resistant bacteria and the few conventional antibiotics being currently developed. “This is an example of taking what nature has given us and trying to understand how it works, so we can modify it to be more potent, more stable or more drug-like, to use as an alternative to what we have in our pharmacy now”. Henriques pointed out.
This research leaded by David Andreu, head of the Proteomics and Protein Chemistry Research Group at UPF, and involving researchers from Australia, Portugal, Brazil and France, was published in the Journal of Biological Chemistry -CS/PRBB-
Pérez-Peinado C, Almeida S, Domingues M, Benfield A, Freire JM, Radis-Baptista G, Gaspar D, M Castanho, Craik D, Henriques S, Veiga A, Andreu D. Mechanism of bacterial membrane permeabilization of crotalicidin (Ctn) and its fragment Ctn[15-34], antimicrobial peptides from rattlesnake venom. Journal of Biological Chemistry, February 2018.