News
6/4/2018

DCEXS-UPF: Discovered the evolutionary origin of a key mechanism in the embryonic brain development in a group of fish

DCEXS-UPF: Discovered the evolutionary origin of a key mechanism in the embryonic brain development in a group of fish


News from DCEXS-UPF


The evolutionary origin of the division of the hindbrain, the most posterior brain vesicle which during embryonic development s divided into seven segments called rhombomeres, has been discovered. “We found that the emergence, over 200 million years ago, of chromosome rearrangement in a large family of freshwater fish resulted in the reuse of a group of genes (rac3b/rfng/sgca) for this system of segmentation of the hindbrain”, explain Cristina Pujades, from DCEXS-UPF, and Juan Ramón Martinez-Morales, from the Andalusian Center for Development Biology, co-leaders of this study.

This research, where scientists from the Paris-Saclay Institute of Neuroscience and Pablo de Olavide University participated too, was published in PNAS-CS/PRBB

 Reference article:

Letelier, J, Terriente, J, Belzunce, I, Voltes, A, Undurraga, C, Polvillo, R, Devos, L, Tena, J, Maeso, I, Retaux, S, Gomez-Skarmeta, JL, Martinez-Morales, JR, Pujades, C. The evolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formationPNAS, March 2018.

More information:
DCEXS-UPF website