News
8/6/2018

CRG: Deciphering the role of cohesin in the 3D organisation of the genome allows for a better understanding of tumour cells

CRG: Deciphering the role of cohesin in the 3D organisation of the genome allows for a better understanding of tumour cells


News from CRG


In recent years it has become evident that the spatial organisation of the genome is key for its function. This organisation depends on a number of factors, the cohesin protein complex being one of them. This essential complex is present in the cells in two versions that contain either the SA1 or SA2 subunit.

The different role of the SA1 and SA2 cohesin variants in the organisation of the genome has been dissected for the first time ever. “Without knowing the function of each of the variants of cohesin, it is very difficult to decipher its role in carcinogenic processes. This work brings us closer to this objective and is a new example of how the study of the 3D organisation of the genome contributes to a better understanding and characterisation of the regulation of genes” highlights Marc A. Marti-Renom, head of the Structural Genomics group at the CNAG-CRG and co-leader of the study.

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Reference:
Kojic et al. “Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organizationNature Structural and Molecular Biology. 2018. DOI: 10.1038/s41594-018-0070-4.