News from ISGlobal
A new study, led by the Barcelona Institute for Global Health (ISGlobal) has developed and externally validated a conceptual model of the dyspnoea-inactivity vicious circle in patients with chronic obstructive pulmonary disease (COPD). According to the World Health Organisation, COPD is the third leading cause of death worldwide. This new study is the first to develop a model of the vicious circle theory in this disease.
COPD is characterised by chronic airflow limitation and persistent respiratory symptoms that limit the patient’s activities. This reduction in physical activity causes the patient’s physical condition to worsen, thereby further exacerbating the respiratory symptoms. This process is known as the “disease spiral” or “vicious circle” theory in COPD.
Previous descriptions of this process were based on expert opinion, clinical observations and cross-sectional studies. However, the theory had never been validated prospectively in accordance with the scientific method.
Maria A. Ramon, et.al. The dyspnoea–inactivity vicious circle in COPD: development and external validation of a conceptual model. European Respiratory Journal 2018 52: 1800079