News from the CRG
With age, our tissues lose their function and capacity to regenerate after being damaged. A study published today in Cell by scientists at the Institute for Research in Biomedicine (IRB Barcelona) and the Centro Nacional de Análisis Genómico of the Centre for Genomic Regulation (CNAG-CRG) explains how dermal fibroblasts age.
The main conclusion drawn is that these fibroblasts lose their cell identity, as if they had “forgotten” what they are, and consequently their activity is altered, thus affecting tissue. The study reveals the cellular and molecular pathways affected by ageing and proposes that they could be manipulated to delay or even reverse the skin ageing process.
Holger Heyn, team leader at the CNAG-CRG and co-leader of the study, explains that “cutting-edge technologies allow molecular analysis of individual cells. In this study, we have applied advanced techniques to obtain high resolution images of fibroblasts as they age”.
Marion Salzer, et.al. Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging. Cell (2018)