News from UPF
Protein-protein interactions play an important role in various functions of a cell. Thus, the identification of the network of interactions that occur among the many proteins of a given organism, also called interactome, it is vital to identify key molecular mechanisms in a biological system.
In an article published in the Journal of Molecular Biology, researchers from CEXS-UPF and the GRIB (UPF-IMIM) coordinated by Baldomero Oliva, head of the research group of Structural Bioinformatics, describe the development of a very accurat predictive tool for this kind of interactions.
The researchers found that the entire protein is involved in the recognition and subsequent binding of another protein and not only the direct interface of the corresponding contact surfaces of each protein. "We have developed a fairly accurate prediction tool to know whether or not two proteins can interact. The key to achieving this level of success was to extract information from both, pairs of proteins that interact, as well as pairs who do not", explains Baldo Oliva.
UPF Nota de Premsa in Catalan
Planas-Iglesias J, Bonet J, García-García J, Marín-López MA, Feliu E, Oliva B. (2013), "Understanding Protein-Protein Interactions Using Local Structural Features", J Mol Biol , 23 de gener, doi: 10.1016/j.jmb.2013.01.014.