Gene vital for post-stroke recovery identified for the first time

Gene vital for post-stroke recovery identified for the first time

News from IMIM

Having certain specific variants of the PATJ gene predisposes to worse recovery from ischemic stroke. This multicentre study coordinated by researchers at the Hospital del Mar Medical Research Institute (IMIM) and doctors from the Hospital del Mar is the most important research carried out so far in the field of genetics and stroke prognosis, and the first published: it uses data from more than 2,000 patients and involves 12 centres from around the world.

They analysed the degree of disability after three months of more than 2,000 patients with ischemic stroke -caused by the blockage of a cerebral artery and which represents 88% of total strokes- by studying multiple clinical factors and genetic data.

"The PATJ gene shows several variants that significantly influence recovery in patients", says Dr. Jiménez Conde. It is a gene involved in cell binding that has a strong presence in nervous tissue.

"In the future, these variants could be used as biomarkers for stroke sufferers, and, depending on the presence of risk alleles (alternative forms of a gene) in each individual, rehabilitation strategies could be personalised.", says Dr. Marina Mola-Caminal, first author of the study. 


Marina Mola-Caminal et al. PATJ Low Frequency Variants Are Associated with Worse Ischemic Stroke Functional Outcome: A Genome-Wide Meta-Analysis. Circulation Research. 2018

More information:
IMIM website