News from CRG - UPF
The union of an ovule and a spermatozoon initiates a complex cell division process that will ultimately yield a new living being. In fact, all the body’s cells come from embryonic stem cells that must be divided, in a controlled and exact fashion, to give rise to proper organ and tissue formation in the embryo. However, the way that stem cells manage to control this accelerated division process without losing control, as occurs with tumour cells, and how division speed is adapted to the energy and molecular supplies they have at all times, are questions as yet unanswered by science.
In this regard, a group of scientists from the Centre for Genomic Regulation (CRG), part of the Barcelona Institute of Science and Technology (BIST), led by the ICREA Research Professor Luciano di Croce, Sergio Aranda, lead author and co-leader of the study, and Eduard Sabidó, head of the CRG/UPF Proteomics Unit, have identified a molecular mechanism that regulates stem cell division speed. Their discovery, published in the Science Advances journal, could have a major impact on research into infertility.
Aranda S, Alcaine-Colet A, Blanco E, Borràs E, Caillot C, Sabidó E, Di Croce L. Chromatin capture links the metabolic enzyme AHCY to stem cell proliferation. Science Advances, 5:eaav2448 (2019)