News from DCEXS-UPF
Initial results from treating endometriosis in mice with cannabinoids suggest they can alleviate some symptoms of the disease, according to a new study in the open-access journal eLife.
The findings have led to the start of a clinical trial in collaboration with the Gynecology Service of the Hospital Clinic of Barcelona, Spain. This trial will evaluate the possible benefits of the naturally occurring cannabinoid ∆9-tetrahydrocannabinol (THC; the main psychoactive constituent of the cannabis plant) in women with endometriosis.
"With a lack of effective treatments, women with endometriosis usually rely on self-management strategies like dietary changes or exercise", explains senior author Rafael Maldonado, Professor at the UPF. Although cannabis comes with a large number of potential side effects, its medicinal properties could provide pain relief in endometriosis and other conditions.
"Together, our findings show that THC limits the development and symptoms of endometriosis in an experimental model and highlight the interest of conducting further research to ensure the safety and beneficial effects of this treatment in women with endometriosis", concludes first author Alejandra Escudero-Lara, a PhD student at the UPF.
Escudero-Lara A, Argerich J, Cabañero D, Maldonado R. Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain eLIFE. https://doi.org/10.7554/eLife.50356