News from IMIM
Researchers at the Hospital del Mar Medical Research Institute (IMIM) participate in the Disc4All project: training network to advance integrated computational simulations in translational medicine, applied to intervertebral disc degeneration.
Disc4All aims to integrate available data and computational simulations on back pain caused by intervertebral disc degeneration with a multidisciplinary translational medicine approach. On the one hand, the unique population cohort data from Twins UK (King's College London) and from the Northern Finland Birth Cohorts (University of Oulu) will be exploited to generate matching sets of molecular profiles and specific intervertebral disc phenotype. On the other hand, cell and organ culture laboratory experiments will be used to pinpoint the most likely relationships among molecular profiles and cell microenvironments. Computer simulations will integrate these population and experimental data, to predict the cell microenvironments through multiscale modelling, and to extract the causality between the emergence of specific molecular activity and specific intervertebral disc phenotypes.Finally, data mining and artificial intelligence techniques will generate interpretable correlation models between measurable clinical data and unmeasurable, but predicted, key regulators of cell and molecular activities. The final output shall be identification of rational patient-specific maps of concurring risk factors.