News from IMIM and DCEXS-UPF
G protein-coupled receptors (GPCRS) are one of the key elements mediating basic stimuli like our response to mosquito bites or to this last-minute goal scored by our favorite football team. In fact, these proteins are the target of almost 40% of the currently approved drugs. However, until now, researchers did not have access to a tool employing molecular simulations to achieve a better understanding of GPCR function.
Therefore, a consortium of researchers from 23 different institutions of 10 different European countries and the United States have joined forces to design and build a tool that will help improve our understanding of the function of these receptors, which are responsible of transmitting signals to the interior of cells.
Dr. Jana Selent, Miguel Servet researcher at IMIM and main corresponding author of this study explains: "we have used state-of-the-art technology that requires highly specific knowledge, like molecular simulations, to build an online resource where scientists from different disciplines can easily inspect and analyze a comprehensive set of molecular simulations of GPCRs".
Rodriguez-Espigares et al. GPCRmd unveils the dynamics of the 3D-GPCRome. 2020, Nature Methods