News
24/5/2013

CEXS-UPF: The ion channel TRPV4 acts as a thermosensor when interacting with membrane lipids

CEXS-UPF: The ion channel TRPV4 acts as a thermosensor when interacting with membrane lipids


News from UPF


We detect rapid changes in temperature within a wide range, allowing us to sense from cold snow to sun heating at the beach. TRP ion channels are behind the molecular identity of the proteins that confer thermosensation. One of these channels, TRPV4, detects temperature in the physiological range (27-40ºC) but it was not known whether the channel is a true thermosensor or a downstream effector of a yet unknown body temperature sensor.

A research study, led by the Molecular Physiology and Channelopathies Laboratory of the UPF Department of Experimental and Health Sciences, has unravelled the basic mechanism of TRPV4 activation by warm temperature. The study in which researchers from Harvard University also collaborated, has been published on 20 May in the Proceedings of the National Academy of Sciences (PNAS). The UPF researchers of this scientific article are Anna Garcia-Elias, Sanela Mrkonjic, Carlos Pardo, Cristina Plata, Fanny Rubio-Moscardo, Rubén Vicente and Miguel A. Valverde.

More information:
UPF press release 

Reference study:
Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli. Anna Garcia-Elias, Sanela Mrkonjić, Carlos Pardo-Pastor, Hitoshi Inada, Ute A. Hellmich, Fanny Rubio-Moscardó, Cristina Plata, Rachelle Gaudet, Rubén Vicente and Miguel A. Valverde. PNAS. doi: 10.1073/pnas.1220231110 . 20/5/2013.